Study on the antitussive and expectorant activities and mechanism of platycodin D based on metabolomics method / 药学学报

In this paper, the antitussive and expectorant activity of platycodin D (PD) were studied by constructing a mouse cough induced by concentrated ammonia water and a mouse trachea phenol red excretion model. The mechanism of antitussive and expectorant effect of PD was studied by metabolomics. The animal experiment was approved by the Animal Ethics Committee of Jiangxi University of Chinese Medicine (approval number: JZLLSC-20220739). Then mice were randomly divided into the normal, model, positive drug, PD low-dose, PD medium-dose and PD high-dose group. The antitussive and expectorant effects of PD were evaluated using a cough mouse model induced by concentrated ammonia water and a mouse tracheal phenol red excretion model, respectively. UHPLC-LTQ-Orbitrap-MS was used to identify the metabolites of mouse lung tissue, and multivariate statistical analysis method of orthogonal partial least squares discriminant analysis (OPLS-DA) was used for metabolites profile analysis. The differential metabolites were screened by variable projected importance value (VIP) and t-test results. Pathways for enrichment of differentiated metabolites were analyzed using the MetaboAnalyst platform. The comparative method was applied to analyze the differences in mechanisms of PD, Deapio-platycodin D (DPD) and total platycosides fraction. The results showed that PD at different concentrations could significantly prolong (P < 0.05) the incubation period of cough mice induced by ammonia water, reduce the coughs frequency, and significantly increase (P < 0.05) the amount of phenol red excretion in phenol red excretion model mice. PD could regulate 6 metabolic pathways of phenylalanine, tyrosine and tryptophan biosynthesis, linoleic acid metabolism, phenylalanine metabolism, glycerophospholipid metabolism, and tyrosine metabolism to exert antitussive effect. It could also regulate 8 metabolic pathways of linoleic acid metabolism, glyoxylic acid and dicarboxylic acid metabolism, glycerol phospholipid metabolism, citric acid cycle and arachidonic acid metabolism to exert an expectorant effect. However, only linoleic acid metabolism and glycerophospholipid metabolism could be regulated by the PD, total platycosides fraction and DPD, which may be ascribed to the structural difference of the platycosides and the interaction between platycosides and the intestinal microbiota. Functional analysis showed that these metabolic pathways are closely related to the regulatory mechanisms of anti-inflammatory response, immune function regulation, neurotransmitter release, cell signal transduction, energy metabolism and cell apoptosis. This study shows that PD possesses good antitussive and expectorant activities. In addition, the mechanism difference of PD, total platycosides fraction and DPD imply that the apiose in PD and the interaction between PD and intestinal microbiota could exert an important effect on the antitussive and expectorant mechanism of the platycosides.

Sick individuals and sick populations: Yunnan unexplained sudden death from the perspective of population medicine / 中华地方病学杂志

Individuals and populations affected by Yunnan unexplained sudden death have different causes, so different research methods and control strategies should be adopted for these two different causes. By reviewing relevant research literature on Yunnan unexplained sudden death, we reinterpret some characteristics of the disease from the perspective of population medicine. At the same time, it is found that some studies have shown that residents in areas where sudden death occurs have a higher proportion of myocardial damage compared to control areas, making them a population with basic sickness. Population medicine methods can be used to conduct etiology research and disease prevention and control.

The Effect of Pharmacists’ Explanation on Young Patients Switching to Generic Drugs Usage / 医薬品情報学

Objective: To keep medical costs down, it is important to promote the use of generic drugs at pharmacies, where prescription volumes are high. However, many parents do not opt for generic drugs. This study examines the effectiveness of pharmacists’ explanations to parents, with the aim of promoting the use of generic drugs among young patients under the age of 20.Method: A questionnaire-based survey was conducted from November 25 to December 1, 2019, at 129 pharmacies.Results: During the survey period, 91 pharmacies received 4,491 prescriptions from young patients. The percentage of generic drugs dispensed per prescription was lower for the young patients than for adult patients (65.4% vs. 70.4%; p < 0.001). Statistically, the percentage of prescriptions dispensed using generic drugs was higher in pharmacies that explained costs, equivalence of quality and efficacy, safety, side effects, and the trial system (divided dispensing), compared to pharmacies that did not use these explanations. Conversely, the percentage of prescriptions dispensed using generic drugs was lower at pharmacies that explained dosage form and ease of swallowing. Many pharmacies explained the equivalence of quality and efficacy (85.7%), with many questions from parents (82.4%). However, only a few pharmacies explained the trial system (divided dispensing) (1.1%), with no questions raised by parents (0.0%).Conclusion: This study found that pharmacists’ explanations are effective in promoting the use generic drugs for young patients. However, there is a lack of awareness among parents about the trial system (divided dispensing), and public institutions and pharmacists are not responding appropriately. To promote generic drug usage among young patients, it is important to develop educational tools regarding the trial system (divided dispensing), create awareness campaigns for parents, and revise medical fee. Furthermore, to ensure safe drug therapy, pharmacists should also provide information on the appearance and taste of generic drugs.

Expert consensus for Jiegu Qili Tablets (Capsules) in treatment of fracture in clinical practice / 中国中药杂志

Fracture is one of the common diseases in the department of orthopaedics and traumatology. Jiegu Qili Tablets(Capsules) are a Chinese patent medicine commonly used to treat fractures in clinical practice, which has been included in the Class A drugs of the catalog of medicines covered by the National Medical Insurance System. However, no consensus or guideline has yet been developed to guide clinicians based on an evidence-based approach in detail, which has severely limited the clinical value of this drug. According to the guiding principle of evidence as the key, consensus as the supplement, and experience as the reference, a consensus was developed in strict accordance with the steps stipulated in the expert consensus on clinical applications of proprietary Chinese medicines. Based on literature review and questionnaire survey, the consensus was a timely summary of the existing clinical evidence on the treatment of fractures with Jiegu Qili Tablets(Capsules), and incorporated the treatment experience of a number of clinical experts. The preparation process took more than a year and the consensus(GS/CACM 293-2021) was officially released by the China Association of Chinese Medicine in September 2021, with the participation of multidisciplinary experts from 27 organizations of Chinese and Western medicine and research institutions. This article introduces the background and objectives of the consensus in detail, and describes the main process of proposal, drafting, expert consensus, and consultation. In particular, 5 consensus recommendations and 12 consensus suggestions are formed with regard to the key issues of indications, treatment timing, dose, duration, and safety in the clinical application of Jiegu Qili Tablets(Capsules) for the treatment of fractures, which guide and standardize the rational use by clinicians and improve the accuracy and safety of drugs.

Las representaciones sociales y la lógica de la explicación / Social representations and the logic of explanation

El artículo aporta respuestas a la pregunta ¿Cuál es la potencia explicativa de la teoría de las RS? Se enumeran diversas aplicaciones de las RS como constructos de significación colectiva del sentido común de las personas. Se apela a las problemáticas clásicas abordadas y los distintos campos disciplinares que abarcan. La potencia explicativa de las RS se analiza en términos de las diferentes lógicas de la explicación que implican las escuelas psicológicas y sociales que se compatibilizan con las RS. Se analiza el método comparativo como lógica explicativa y técnica que potencia las explicaciones para fenómenos que asocian RS y diversas teorías. La posmodernidad presenta innumerables desafíos a las ciencias humanas. Las RS pueden contribuir para varios de ellos demostrando ser una técnica poderosa. La actualidad de las RS consiste en develar los sentidos implicados en el sentido común contribuyendo a la comprensión del mundo actual y su gobernanza AU

The article provides answers to the question: What is the explanatory power of the SR theory? Various applications of SR are listed as constructs of collective meaning of people's common sense. It appeals to the classic problems addressed and the different disciplinary fields they cover.The explanatory power of the SR is analyzed in terms of the different logics of the explanation implied by the psychological and social schools that are compatible with the SR.The comparative method is analyzed as an explanatory and technical logic that enhances explanations for phenomena that associate SR and various theories.Postmodernity presents myriad challenges to the human sciences. RS can contribute to several of them proving to be a powerful technique. SR today consists of unveiling the meanings involved in common sense, contributing to the understanding of the current world and its governance AU

Standard interpretation of radiological protection requirements for the production places of rare earths / 中国辐射卫生

Chinese national standard GBZ139—2019 Radiological Protection Requirements for the Production Places of Rare Earths was published to replace GBZ 139—2002 Radiological Protection standards for the production places of rare-earth elements and implemented from April 1, 2020. Herein, background on which the new standard was based, the main modifications and the foundations were explained. More specific requirements for the production places of rare earths were stipulated in the new standard, which will play an important role in occupational health protection of the workers engaged in the mining, mineral processing and smelting of rare earths.

Contingência cultural de três termos: Uma proposta de explicação comportamentalista da cultura / Cultural three-terms contingency: A proposal of culture behavioral explanation

O interesse pelo estudo da interface entre a ontogênese e a cultura, e mais especificamente pelos aspectos culturais, ensejou a constituição de uma área de pesquisa que tem sido denominada Análise Comportamental da Cultura. A despeito desse esforço analítico, ainda não há uma explicação consensual de cultura de acordo com os pressupostos do comportamentalismo radical. Com base na análise de textos de Skinner sobre o nível cultural, o objetivo do artigo consistiu em mostrar que a explicação skinneriana da cultura pode ser acomodada na estrutura de uma contingência cultural de três termos. A cultura, então, passa a ser entendida a partir da inter-relação probabilística entre práticas culturais, condições do ambiente físico e social e as consequências culturais que operam a partir do valor de sobrevivência da cultura. Essa explicação possibilita não só uma compreensão da cultura, mas também de como acontece a evolução cultural. Assim, a cultura apresenta-se como um nível de variação e seleção com características próprias, tendo temporalidade e complexidade diferentes do nível ontogenético e filogenético e, portanto, necessitando de um nível específico de análise.

The interest in the study of the interface between ontogenesis and culture, and more specifically the cultural aspects, led to the constitution of a research area that has been called Behavioral Analysis of Culture. In spite of this analytical effort, there is still no consensual explanation of culture according to the assumptions of radical behaviorism. Based on the analysis of Skinner's texts on the cultural level, the aim of the article was to show that the Skinnerian explanation of the culture can be accommodated in the structure of a threefold cultural contingency. Culture, then, comes to be understood as the probabilistic interrelationship between cultural practices, conditions of the physical and social environment and the cultural consequences that operate from culture's survival value. This explanation enables not only an understanding of culture, but also of how cultural evolution happens. Thus, culture presents itself as a level of variation and selection with its own characteristics, having different temporality and complexity from the ontogenetic and phylogenetic levels and, therefore, requiring a specific level of analysis.

Editorial explanation for clinical practice guideline for stable chronic obstructive pulmonary disease with traditional Chinese medicine / 中国中药杂志

As an important auxiliary document in the process of guideline development, the editorial explanation is the extension and complement to the content of the guideline, a basis for fully understanding the technical content of the guideline, an indispensable document for the guideline's traceability. The project team of this guideline, while formulating the Clinical practice guideline for stable chronic obstructive pulmonary disease with traditional Chinese medicine(draft version for comments), also has written the corresponding editorial explanation. In order to enable the relevant medical workers to more accurately understand and apply the guideline, but also to provide readers with a more in-depth understanding of the reasons and processes for the development of the guideline, the paper will give a detailed introduction to the compilation process about the guideline, includes: work overview(project background, task source, drafting and collaboration unit, project team members and their division of labor), main technical content(the basis and principles of guideline development, technical route), main compilation process(the establishment of project team, the formulation of the guideline plan, the project approval and the registration of research programme, the construction of clinical issues and the selection of outcome indicators, evidence search screening and synthesis, evidence evaluation and grading, the formation of recommendations, the writing of exposure draft, external review and self-assessment, etc), expert consensus implementation requirements and measure suggestions(promotion and implementation measures, and post-effect evaluation), other issues need to be explained and so on.

Genetic relatedness and its causal role in the evolution of insect societies

It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonicstage (Singh and Zacouto in J. Biosci. 35 315–319, 2010). As such, age reprogramming stands apart from the inducedpluripotent stem (iPS) and nuclear transfer-embryonic stem (NT-ES) cell therapies where histo-compatible cells are produced only after passage through an embryonic stage. It avoids many of the disadvantages associated with iPS and NT-EScell therapies. Experimental evidence in support of age reprogramming is burgeoning. Here, we discuss possible newapproaches to enhance age reprogramming, which will have considerable benefits for regenerative therapies.

Mediclaim insurance challenges and solutions – Doctors supporting patients: A Medic LAWgic initiative

INTRODUCTION:Because patients covered by medical insurance are being denied legitimate claims, doctors are working shoulder to shoulder with them and have garnered significant experience in this matter. We, therefore, decided to a systematic survey under the Medic LAWgic banner and presented the data.METHODS:A short, 8-question multiple-choice survey was conducted online among doctor clinicians. Duplicate replies were removed. The remaining replies were evaluated, interpreted, and the data are being presented here.RESULTS:A total of 377 doctors responded. The majority (208, 55%) had faced problems with medical insurance claims in more than 10% of their patients. Almost half of them (48%) had outright rejection of the claims in more than 10% of their patients. Reduction in claim amounts was faced in more than 10% instances by 262 (70%). The five most common causes for refusal or rejection of claims included failure of patient to disclose pre-existing illness (234, 62%), other insurance policy terms related issues (157, 42%), oral medication (199, 53%), treatment without admission (155, 41%), and treatment with new modes of therapy (152, 40%). As many as 301/377 (80%) doctors had written letters to the insurance companies for supporting their patients’ claim. Such supporting letters from the treating doctors resulted in the claim being accepted or approved in 216 instances (57%).DISCUSSION:Mediclaim denial is a major and growing problem. People who need financial assistance the most are also the most vulnerable to denial. In the USA, such denial rates ranged from 1% to 45% of in-network claims in the year 2017. Unfortunately, <0.5% of patients appealed such claim denial. The insurance regulatory and development authority of India (IRDA) have issued guidelines that all claims need to be settled within 30 days and that insurance companies must fulfill their contractual commitment for genuine claims, even if timely intimation was not possible. Insurance companies are running a business for profit. Hence, even the most expensive plans will have a list of exclusions, in the fine print. Indian patients need to be proactive in following up when claims are rejected or reduced. Doctors are their pillar of support, whose advantage needs to be taken by them. IRDA and consumer courts are also looking after patients’ rights in this matter.CONCLUSION:Patients are increasingly facing challenge of medical insurance companies denying legitimate claims. Doctors help by writing to the insurance companies supporting their patients claim and such letters help in the majority of instances. Patients and their families need to follow up aggressively when their claims are not approved, rejected or reduced. They should also request the help of their doctors when facing such challenges.

Reform of clinical courses examination based on Deming cycle theory: An exploration of explanation and evaluation system for examination papers / 中华医学教育探索杂志

Deming cycle theory, namely the plan-do-check-act (PDCA) cycle theory, is a relatively advanced and widely used theory of quality management system in foreign countries, with both scientific and systematic features. The research group introduced the PDCA quality control theory into the eight-year clinical course assessment for the first time to carry out the reform of clinical course examination and actively promote the explanation and evaluation system for examination papers. After four years of follow-up research, the management means based on the PDCA cycle was continuously used to optimize the explanation and evaluation system for examination papers and improved the efficiency of clinical course examination. At present, certain achievements have been made, which include urging students to reflect on learning, promoting the implementation of the student-centered teaching philosophy, enhancing teachers' teaching input, and improving the management quality of teaching departments.

Editorial explanation for Expert consensus statement on Diemailing Kudiezi Injection in clinical practice / 中国中药杂志

Expert consensus statement on Diemailing Kudiezi Injection in clinical practice was approved on April 17,2019 by the Standardadization Office of the Chinese Association of Chinese Medicine. This project,which started in November 2017,has been developed and completed in accordance with the standard developing procedure. This paper will give a detailed introduction to the compilation process about the consensus. The aim is to enable readers to understand the background,purpose and basis of this consensus in a timely manner. Readers can learn about diffferent stages of develping process,including project management system,drafting,consulting,expert consensus,as well as current problems and shortcomings. Such an editorial explanation is just a dynamic follow-up of the whole consensus-making process. It also plays a good supervisory role in the whole consensus-making. It could be a guarantee for the quality of the consensus. There is no doubts that the editorial explanation is an important auxiliary document in the process of consensus-making. It is the extension and supplement of consensus content and a basis for fully understanding the technical content of this consensus. Therefore it is an indispensable document in the process of consensus-making.

Guidance of instructions for compiling expert consensus on clinical practice of Chinese patent medicine of China Association of Chinese Medicine / 中国中药杂志

The expert consensus on clinical practice of Chinese patent medicines shall be regarded as the same with clinical practice guidelines,which shall be concise,readable and applicable. Therefore,a formal expert consensus is unable to contain the whole compilation process and the content of its important process documents. It is necessary to write instructions for continuation,expansion and publicity. In 2018 Standardization Department of China Association of Chinese Medicine invited methodologists with the background of evidence-based medicine drafted a series of standards for expert consensus on clinical practice of Chinese patent medicines,including the guidance for compilation the instructions. It will be useful for readers of expert consensus to understand the work behind the compilation,so as to make the compilation process more transparent and standardized. We proposed nine requirements for compilation the instructions,namely content and requirements,work overview,main technical content,compilation process,process and basis for handling major disagreements,expert consensus implementation requirements and measure suggestions,other issues need to be explained,appendix and format for instructions.

Reform of clinical courses examination based on Deming cycle theory:An exploration of explanation and evaluation system for examination papers / 中华医学教育探索杂志

Deming cycle theory, namely the plan-do-check-act (PDCA) cycle theory, is a relatively advanced and widely used theory of quality management system in foreign countries, with both scientific and systematic features. The research group introduced the PDCA quality control theory into the eight-year clinical course assessment for the first time to carry out the reform of clinical course examination and actively promote the explanation and evaluation system for examination papers. After four years of follow-up research , the management means based on the PDCA cycle was continuously used to optimize the explanation and evaluation system for examination papers and improved the efficiency of clinical course examination. At present, certain achievements have been made, which include urging students to reflect on learning, promoting the implementation of the student-centered teaching philosophy, enhancing teachers' teaching input, and improving the management quality of teaching departments.

Protocolo de observación de la función de explicación (PROFE): un instrumento para operacionalizar la transmisión de contenidos por parte del profesorado / Observation Protocol of the Explanation Function (OPEF): An Instrument to Operationalize the Transmission of Contents by Teachers

Resumen La calidad de la docencia universitaria es fundamental dentro del proceso educativo, lo que exige la evaluación del profesorado, prefiriéndose la metodología observacional cuando se evalúa la conducta de este. El objetivo de este estudio consistió en el análisis pormenorizado de la función docente de explicación, de especial relevancia dentro el escenario educativo, lo que hace importante su análisis. Para ello, se utilizó el instrumento observacional PROFE, para medir los recursos y estrategias utilizados durante la explicación. Se ha puesto a prueba la bondad psicométrica del instrumento mediante fiabilidad, homogeneidad y se ha optimizado el número de sesiones y el tiempo, para posteriormente analizar la conducta de cinco profesores de la Universidad de La Laguna.

Abstract The quality of university teaching is a very important aspect inside the educational process. This aspect makes it necessary the evaluation of teaching professionals. The observational methodology is the one used for evaluation. The objective of this study is the detailed analysis of one teaching function, the explanation. It is a function of particular relevance in the educational setting, so it is very important to analyze it. For that, the instrument PROFE was utilized. It allows the measurement of the resources and strategies used during the explanation. The instrument psychometric goodness has been tested calculating reliability and homogeneity. The number of sessions and time have been optimized. For later the behavior of five professors of La Laguna University has been analyzed.

Críticas de Skinner e Merleau-Ponty à Causalidade / Las criticas de Skinner y Merleau-Ponty a la causalidad / Skinner and Merleau-Ponty's criticism of causality

Resumo Encontra-se, tradicionalmente, uma forte identificação entre explicação e causa, tanto na filosofia, quanto na ciência e no senso comum. Contudo, revisões críticas instauradas no âmbito da filosofia da ciência, particularmente a partir do século XX, questionam essa identificação tácita, de modo que uma explicação científica não implica necessariamente em apontar causas. Exemplos dessa compreensão aplicados a discussões com relação a fenômenos psicológicos podem ser encontradas em diferentes tradições, como a fenomenologia-existencial de M. Merleau-Ponty, e o comportamentalismo radical de B. F. Skinner. Este trabalho busca salientar a crítica em relação ao pensamento causal, discutindo seu papel fundamental para a abordagem do comportamento como fenômeno com sentido próprio, como pretendido nessas duas perspectivas. Em ambas as abordagens, explicar não é encontrar as causas, mas descrever, a estrutura do comportamento, para Merleau-Ponty, ou as contingências de reforçamento, para Skinner. Nesse sentido, indica-se essa postura crítica como elemento favorecedor de possíveis aproximações e diálogos entre essas diferentes perspectivas.

Resumen Observase tradicionalmente una identificación fuerte entre explicación y causas, tanto en la filosofía cuanto en la ciencia y el sentido común. Sin embargo, revisiones críticas desde la filosofía de la ciencia, sobre todo a partir del siglo XX, cuestionaron esta identificación tácita, por lo que una explicación científica no implica necesariamente apuntar causas. Ejemplos de esta comprensión aplicada a los debates sobre los fenómenos psicológicos pueden ser encontrados en diferentes tradiciones, como la fenomenología existencial M. Merleau-Ponty, y el conductismo radical de B.F. Skinner. En este trabajo se pretende dar a conocer la crítica del pensamiento causal, discutiendo su papel clave en el enfoque de la conducta como un fenómeno con su propio sentido, como pretendido en esas dos perspectivas. En ambos enfoques, explicar no es encontrar las causas, sino que describir la estructura de la conducta, para Merleau-Ponty, o las contingencias de reforzamiento, para Skinner. En este sentido, se indica esta posición crítica como elemento favorecedor de aproximaciones posibles y diálogos entre estas diferentes perspectivas.

Abstract A strong connection between explaining phenomena and identifying causes is commonly observed not only in philosophical, but also in scientific and common sense discourse. Nonetheless, critical analyses conducted in philosophy of science, especially as of the twentieth century, questioned this tacit connection, to the effect that a scientific explanation does not necessarily imply identifying causes. Examples of this viewpoint applied to discussions of psychological phenomena can be found in various traditions, such as M. Merleau-Ponty's existential-phenomenology and B. F. Skinner's radical behaviorism. The present paper seeks to highlight the criticism of causal theories, discussing the fundamental contribution of such criticism to treating behavior as a phenomenon with its own sense, as was proposed in Merleau-Ponty and Skinner's approaches. Both approaches claim that explaining behavior does not signify identifying causes, but rather describing either the structure of behavior, according to Merleau-Ponty, or the contingencies of reinforcement, according to Skinner. Along these lines, we recommend such criticism as an element favoring potential closeness and dialogue between these different perspectives.

"¿Sabés qué es ?" Explicaciones de niños tutores en torno a vocabulario no familiar. Un estudio con niños de poblaciones urbano marginadas de Argentina / "Do you know what it is ?" Explanations of child tutors about non familiar vocabulary. A study with children from marginalized urban populations of Argentina

Resumen En el presente estudio se analizan situaciones de alfabetización entre díadas de niños de 12 años, que asistían a la escuela primaria y niños de 5 años de jardín de infantes generadas en el marco del programa de niños tutores en alfabetización "De niño a niño" (Rosemberg y Alam, 2009) orientado a promover el aprendizaje de la lectura y la escritura de niños, quienes viven en poblaciones urbano marginadas de Argentina. El análisis se focaliza en las secuencias de intercambio en las que los niños mayores (tutores) explican palabras poco familiares a los niños pequeños (aprendices) durante dis tintos tipos de actividades: lectura de cuentos y actividades focalizadas en el sistema de escritura y el vocabulario. Durante el año escolar, se llevaron a cabo 7 sesiones y las sesiones de 8 díadas fueron filmadas y transcriptas. Se identificaron 89 secuencias donde el tutor explicaba una palabra al apren diz. Para el análisis, se elaboró una categorización que da cuenta de la estructura conversacional de las secuencias de explicación -modalidad monologal o dialogal- y del tipo de información empleada -estrategias que recurren a aspectos semánticos y de contextualización. A fin de comparar cómo se despliegan estas secuencias en cada tipo de actividad, se emplearon pruebas estadísticas no paramé tricas. Los resultados mostraron una preeminencia de la modalidad monologal y un mayor empleo de estrategias que recurren a aspectos semánticos en las situaciones de lectura. En las otras actividades de alfabetización, prevaleció la modalidad dialogal y el empleo de estrategias de contextualización.

Abstract: This study analyzes literacy situations between dyads of 12-year-olds attending primary school and 5-year-old kindergarten children generated in the framework of the "De niño a niño" program (Rosemberg & Alam, 2009). The goal of this program is to promote reading and writing learning among children living in urban-marginalized populations in Argentina. The analysis focuses on the interventions used by older children (tutors) to explain un familiar words to younger children (apprentices) in the context of different types of activities: reading stories and activities focused on the writing system and vocabulary. During the school year, 7 sessions were held. The tutoring sessions of 8 dyads were videotaped and transcribed. Eighty-nine exchanges in which a tutor explained a word to the apprentice were identified. For the analysis, a categorization was elaborated focusing on the conversational structure of the explanation sequence modality - monologal or dialogal - and the type of information used for the explanation -strategies that resort to semantic and contextual aspects. In order to compare how these sequences were deployed in each type of activity, nonparametric statistical tests were used. The results showed a pre-eminence of the monologal modality and a greater use of strategies that resort to semantic aspects in reading situations. In the other literacy activities, the dialogal modality and the use of contextual aspects prevailed.

Generación de inferencias explicativas en la comprensión de textos expositivos: el rol de la memoria de trabajo y el conocimiento previo específico / Explanation-based inferences generation in expository texts comprehension: The role of working memory and specific prior knowledge

RESUMEN El propósito de este trabajo consistió en estudiar la relación entre la memoria de trabajo, el conocimiento previo y la generación de inferencias en la comprensión de textos. Con este propósito, 167 estudiantes universitarios completaron pruebas de memoria de trabajo y cuestionarios sobre su conocimiento acerca del cambio climático y de astronomía; luego de la lectura de dos textos expositivos referidos a ambos temas, completaron un cuestionario sobre inferencias. Los resultados del análisis de correlaciones y del análisis de senderos muestran que si bien la memoria de trabajo y el conocimiento previo específico de dominio tienen una relación con la generación de inferencias explicativas-repositivas, hay una relación de interacción de mediación entre estas variables que explica el rol de ellas sobre la generación de inferencias.

ABSTRACT The aim of this research is to study the relationship between working memory, previous knowledge, and explanation-based inferences in expository text reading. To this effect, 167 undergraduates completed three working memory tasks, and two climate change and astronomy questionnaires, after reading two expository texts on these subjects. The results of the correlations and paths analyses show that, while working memory and specific previous domain knowledge are related to the generation of explanatory and reinstatement inferences, there is a mediation interaction relationship between these variables that explains their role in the generation of inferences.

How to draft editorial explanation for transparent and concise guideline on clinical practice--Case analysis / 中国中药杂志

Clinical practice guideline (CPG) should be concise and readability, which can be possible to implement CPG into practice smoothly. A formal published CPG can't load its developing process and details. An editorial explanation of CPG is much useful to show details and logic process of developing CPG. Although there are many different standards for developing CPG, being nothing to do with process management of CPG. By referring to editorial explanation on international standards, a request for CPG was investigated in this study. An editorial explanation for clinical practice guideline should be transparency, logic and traceable. A good editorial explanation could make users or readers to learn what goes on behind the scenes. A standardized editorial explanation could supervise the GCP developing and improve the quality of GCP.

Timing of Use of the Term “Palliative Care” for Cancer Patients by Physicians and Nurses in Japan

<p>Palliative care is sometimes difficult for medical staff to say to patients with cancer and their families. The late of using the term “palliative care” decrease the opportunity to know about palliative care for the patients and their families. The primary aims of this study were to reveal physicians’ and nurses’ usage of the term “palliative care”, time to use the term for the first time, and a synonym. We conducted a questionnaire survey to 387 physicians and 518 floor nurses at Hiroshima University Hospital in February, 2010. We analyzed the results of physicians and nurses separately. Two hundred and seventy-two physicians (response rate 70.3%) and 284 nurses (54.8%) answered the questionnaire. Many physicians (77.2%) and the majority of nurses (56.0%) explain with the term “palliative care”. the majority of physicians use the term when cancer cause any symptoms and at early stage. Some nurses (31.4%) couldn’t use the term “palliative care” before physicians explained the term. Nurses having longer experience tend to use the term regardless of physicians’ use. Many physicians use the term “palliative care” at early stage of cancer. Many nurses also use the term at early stage of cancer, but some nurses couldn’t use before physicians’ use.</p>